13 products were found matching "Cay11284-100"!

DNA methylation occurs mainly at the 5'-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding domain 2 (MBD2) protein specifically binds to methylated promoters on CpG islands....

DNA methylation occurs mainly at the 5'-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding protein 2 (MeCP2) specifically binds to methylated promoters on CpG islands and...

Key Features Cayman's CBP bromodomain TR-FRET Assay Kit (Cay-600850) was developed using CREB-binding protein bromodomain (human recombinant) protein.Bulk sizes available upon request The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine...

10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH (Cay-14805), superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 µM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP, Cay-21495) in...

Naphyrone (Cay-10517) is an analog of the psychoactive compound pyrovalerone, characterized by the substitution of the methylphenyl group of pyrovalerone with 2-naphthyl. Like pyrovalerone, naphyrone has been detected in products marketed as party pills or bath salts. Naphyrone 1-naphthyl isomer (hydrochloride)...

CI-994 is an inhibitor of histone deacetylase 1 (HDAC1), HDAC2, and HDAC3 (IC50s = 0.9, 0.9, and 1.2 µM, respectively). It is selective for these HDACs over HDAC8 (IC50 = >20 µM). CI-994 inhibits the growth of HCT116 colon cancer cells but not human mammary epithelial cells (HMECs, IC50s = 4 and >50 µM,...

Irinotecan, a derivative of the alkaloid camptothecin (Cay-11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I. Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1. Irinotecan demonstrates...

Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Cay-10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In addition to being anti-inflammatory, resolvins...

Mouse anti-c-myc IgG clone 9E10 (EQKLISEEDL) conjugated to DyLight(R) 650 Antibody: Mouse monoclonal Anti-C-MYC Clone: 9E10 Isotype: IgG1kappa Reactivity: c-myc tagged proteins Immunogen: 9E10 epitope (EQKLISEEDL sequence) from the human c-myc protein Dye: DyLight(R) 650 Excitation max. lambda: 652 nm Emission max....

UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.Formal Name:...

Substituted cathinones are psychoactive compounds commonly used as recreational drugs. alpha-Ethylaminopentiophenone is a substituted cathinone that is an analog to ethcathinone, differing by having propyl rather than methyl at the alpha position. The physiological and toxicological properties of this compound have...

Rosiglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It activates PPARgamma1 and PPARgamma2 in reporter assays (EC50s = 30 and 100 nM, respectively). Rosiglitazone selectively activates chimeras containing the ligand-binding domains (LBDs) of PPARgamma over PPARalpha and...