2 products were found matching "Cay14492-25"!

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Item number: Cay14922-25

Neutrophil elastase is stored within cytoplasmic azurophilic granules in the neutrophil and released upon stimulation by pathogens where it acts either as free protein or is associated with neutrophil extracellular traps (NETs). Together with other proteases released from activated neutrophils, neutrophil elastase...

Keywords:	1-(3-methylbenzoyl)-1H-indazole-3-carbonitrile
Application:	ELANE inhibitor
CAS	1448314-31-5
MW:	261.3 D

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Afatinib

Item number: Cay11492-25

Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively). It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein. Afatinib (20 mg/kg) reduces...

Keywords:	BIBW 2992,...
Application:	EGFR / HER2 kinase inhibitor
CAS	850140-72-6
MW:	485.9 D

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