BRD4 bromodomain 2 (human recombinant)
ART NR.: Cay11066-25 (25 µg)
Cay11066-50 (50 µg)
Cay11066-100 (100 µg)
MW: 40 kD
UniProt ID: O60885
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Schlagworte: Bromodomain containing protein 4
Recombinant GST-tagged protein expressed in E. coli. The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. These domains function in the linking of protein complexes to acetylated nucleosomes, and thereby controlling chromatin structure and gene expression. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.
Products for: BRD4 - bromodomain-containing protein 4
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