8 products were found matching "Cay11721"!

Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) family. It is a ubiquitously expressed nuclear protein with roles in a variety of cellular processes, including regulation of gene transcription, cell cycle progression, and viral genome segregation. BRD4 is...

Cycloastragenol, the aglycone derivative of astragaloside A (Cay-16677), can be found in various species of Astragalus and is reported to activate telomerase. It has been shown to slow telomere loss, increase replicative capacity, and improve immune function in CD8+ T lymphocytes from HIV-1-infected patients.Formal...

AM2201 (Cay-10707) is a potent synthetic cannabinoid (CB) developed on an indole base with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively. CUMYL-PICA is a derivative of AM2201 with a PINACA-like chain that lacks the alkyl-terminal fluorine atom and where the naphthoyl...

Oleanolic acid is a pentacyclic triterpenoid that has been found in O. europaea and has diverse biological activities. It is active against S. aureus, B. thuringiensis, E. coli, S. enterica, and S. dysenteriae (MICs = 1.9, 1.9, 7.8, 3.9, and 1.9 µg/ml, respectively) and scavenges hydroxyl and superoxide radicals in...

1-Naphthyl 3,5-dinitrobenzoate has been identified as a dual 5-lipoxygenase and microsomal prostaglandin E synthase-1 inhibitor with IC50 values of 1 and 3.6 µM, respectively. The scaffold of this compound is being explored for anti-inflammatory drug design.Formal Name: 1-(3,5-dinitrobenzoate) 1-naphthalenol. CAS...

Jervine is a naturally occurring teratogenic alkaloid that inhibits the sonic hedgehog pathway (IC50s = 500-700 nM) in vitro. It induces a variety of birth defects in vivo, including holoprosencephaly, cyclopia, cebocephaly, exencephaly, and microphthalmia in rat, chicken, and sheep. Jervine also reduces lipid...

Platycodin D is a saponin isolated from the root of P. grandiflorum. Root preparations have been used extensively in Chinese herbal medicine for many applications, particularly for upper respiratory disorders and inflammation. The cellular and physiological actions of purified platycodin D have not been...

Vitamin D3 is a biologically inactive precursor to calcitriol (Cay-71820) that is converted to active metabolites in vivo. Vitamin D3 is obtained from dietary sources, including fish, or formed in the epidermis via photolytic conversion of 7-dehydro cholesterol (Cay-14612) to previtamin D3 by UVB radiation, followed...