7 products were found matching "Cay14864-25"!

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PS-1145
PS-1145

Item number: Cay14862-5

PS-1145 is an IkappaB kinase beta (IKKbeta) inhibitor (IC50 = 88 nM). It selectively inhibits IKKbeta over a panel of 14 kinases (IC50s = >100 nM for all). PS-1145 also inhibits the IKK complex (IC50 = 100 nM). It inhibits the proliferation of MM.1S, U266, and RPMI-8226 myeloma cells when used at concentrations...
Keywords: IKK Inhibitor X, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
Application: IKKbeta inhibitor
CAS 431898-65-6
MW: 322.8 D
From 43.00€ *
Review
Myoseverin
Myoseverin

Item number: Cay14642-5

Myoseverin is a trisubstituted purine which binds microtubules, reversibly altering cellular function. At 20 µM, it directly binds tubulin and disrupts the structure of the microtubule cytoskeleton, resulting in myotube fission. Myoseverin arrests cell cycle in the G2/M phase, followed by DNA synthesis and cell...
Keywords: N2,N6-bis[(4-methoxyphenyl)methyl]-9-(1-methylethyl)-9H-purine-2,6-diamine
Application: Cell cycle arrest
CAS 267402-71-1
MW: 432.5 D
From 48.00€ *
Review
Tamoxifen N-oxide
Tamoxifen N-oxide

Item number: Cay18642-5

Tamoxifen (Cay-13258) is a selective estrogen receptor modulator that evokes tissue-dependent effects. Tamoxifen N-oxide is a metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases. It can be converted back to tamoxifen by cytochrome P450 isoforms and hemoglobin. Like the parent...
Keywords: N-oxide-2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl, ethanamine
Application: Tamoxifen metabolite, hydroxysteroid sulfotransferase 2A1 inhibitor
CAS 75504-34-6
MW: 387.5 D
From 52.00€ *
Review
BRD3 bromodomains 1 and 2 (human, recombinant)
BRD3 bromodomains 1 and 2 (human, recombinant)

Item number: Cay14864-100

Bromodomain-containing protein 3 (BRD3) is a member of the bromodomain and extra-terminal domain (BET) family. It is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple histone acetylation marks to the transcriptional regulation of target promoters, and an...
Keywords: BRD3, KIAA0043, RING3-like protein, RING3-like protein, Bromodomain-containing protein 3, Bromodomain-containing protein 3
Expressed in: E. coli
MW: 75 kD
465.00€ *
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Fusidic Acid (sodium salt)
Fusidic Acid (sodium salt)

Item number: Cay14825-250

Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans...
Keywords: SQ 16,360, (4alpha,8alpha,9beta,13alpha,14beta)-16beta-(acetyloxy)-...
Application: Antibiotic
CAS 751-94-0
MW: 538.7 D
From 43.00€ *
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Teniposide
Teniposide

Item number: Cay14425-25

Teniposide is a topoisomerase II poison. It promotes calf thymus topoisomerase II-mediated DNA cleavage when used at concentrations ranging from 0.04 to 40 µg/ml. Teniposide induces single- and double-stranded DNA breaks in a concentration-dependent manner. It inhibits the proliferation of A549 lung cancer cells...
Keywords: NSC 122819, VM-26,...
Application: Topoisomerase II inhibitor
CAS 29767-20-2
MW: 656.7 D
From 43.00€ *
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PF-04620110
PF-04620110

Item number: Cay16425-25

Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides and has potential roles in obesity, diabetes, and atherosclerosis. PF-04620110 is a potent inhibitor of DGAT-1 (IC50 = 19 nM) that is without effect on DGAT-2. It has high oral bioavailability...
Keywords: trans-4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-cyclohexaneacetic acid
Application: DGAT1 inhibitor
CAS 1109276-89-2
MW: 396.4 D
From 123.00€ *
Review