8 products were found matching "Cay14658-25"!

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XE 991 (hydrochloride)
XE 991 (hydrochloride)

Item number: Cay14582-5

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 µM). It much...
Keywords: 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone, dihydrochloride
Application: KCNQ channel blocker
CAS 122955-13-9
MW: 449.4 D
From 84.00€ *
Review
BRD3 bromodomain 2 (human, recombinant)
BRD3 bromodomain 2 (human, recombinant)

Item number: Cay14658-100

Bromodomain-containing protein 3 (BRD3) is a member of the bromodomain and extra-terminal domain (BET) family. It is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple histone acetylation marks to the transcriptional regulation of target promoters, and an...
Keywords: BRD3, KIAA0043, RING3-like protein, RING3-like protein, Bromodomain-containing protein 3, Bromodomain-containing protein 3
Application: Binding studies
Expressed in: E.coli
MW: 40,7 kD
465.00€ *
Review
Leukadherin 1
Leukadherin 1

Item number: Cay14855-25

Leukadherin 1 is a small molecule allosteric activator of CD11b/CD18 that increases K562 cell adhesion to an endogenous CD11b/CD18 ligand, fibrinogen (EC50 = 4 µM). It increases adhesion and decreases de-adhesion of murine neutrophils, leading to reduced chemotaxis. It acts by reducing the rolling velocity of...
Keywords: 4-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid
Application: Allosteric CD11b/CD18 activator
CAS 344897-95-6
MW: 421.5 D
From 82.00€ *
Review
Fusidic Acid (sodium salt)
Fusidic Acid (sodium salt)

Item number: Cay14825-250

Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans...
Keywords: SQ 16,360, (4alpha,8alpha,9beta,13alpha,14beta)-16beta-(acetyloxy)-...
Application: Antibiotic
CAS 751-94-0
MW: 538.7 D
From 43.00€ *
Review
JWH 081-N-(cyclohexylmethyl) analog
JWH 081-N-(cyclohexylmethyl) analog

Item number: Cay14655-10

JWH 081 (Cay-10579) is a cannabimimetic aminoalkylindole that shows a high-affinity for the central cannabinoid (CB1) receptor with a Ki value of 1.2 nM and ten-fold reduced affinity for the peripheral cannabinoid (CB2) receptor (Ki = 12.4 nM). JWH 081-N-(cyclohexylmethyl) analog is a synthetic CB where a...
Keywords: [1-(cyclohexylmethyl)-1H-indol-3-yl](4-methoxy-1-naphthalenyl)-methanone
Application: Analytical reference standard, Synthetic cannabinoid analog
CAS 1373876-34-6
MW: 397.5 D
From 291.00€ *
Review
Anti-Irisin
Anti-Irisin

Item number: Cay14625-1

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1alpha (PGC-1alpha), regulates mitochondrial biogenesis and function. Expression of the membrane protein fibronectin...
Keywords: Anti-FNDC5, Anti-FRCP2, Anti-Irisin, Anti-Fibronectin type III domain-containing protein 5, Anti-Fibronectin type III...
Application: ELISA, WB
Host: Rabbit
564.00€ *
Review
Loratadine
Loratadine

Item number: Cay15625-25

Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM). It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with...
Keywords: SCH 29851, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid, ethyl...
Application: Histamine H1 receptor antagonist
CAS 79794-75-5
MW: 382.9 D
From 60.00€ *
Review
Silychristin
Silychristin

Item number: Cay34658-25

Silychristin is a flavonolignan that has been found in S. marianum and has diverse biological activities. It inhibits monocarboxylate transporter 8 (MCT8, IC50 = ~100 nM) and MCT8-dependent uptake of the thyroid hormone 3,3',5-triiodo-L-thyronine (T3) in MDCK cells and primary mouse astrocytes (IC50s = 170 and 50...
Keywords: (+)-Silychristin, Silychristin A,...
Application: Bioactive flavonolignan
CAS 33889-69-9
MW: 482.4 D
From 238.00€ *
Review