- Search results for Cay14658-25
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8 products were found matching "Cay14658-25"!
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Item number: Cay14582-5
The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 µM). It much...
Keywords: | 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone, dihydrochloride |
Application: | KCNQ channel blocker |
CAS | 122955-13-9 |
MW: | 449.4 D |
From 84.00€
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Item number: Cay14658-100
Bromodomain-containing protein 3 (BRD3) is a member of the bromodomain and extra-terminal domain (BET) family. It is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple histone acetylation marks to the transcriptional regulation of target promoters, and an...
Keywords: | BRD3, KIAA0043, RING3-like protein, RING3-like protein, Bromodomain-containing protein 3, Bromodomain-containing protein 3 |
Application: | Binding studies |
Expressed in: | E.coli |
MW: | 40,7 kD |
465.00€
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Item number: Cay14855-25
Leukadherin 1 is a small molecule allosteric activator of CD11b/CD18 that increases K562 cell adhesion to an endogenous CD11b/CD18 ligand, fibrinogen (EC50 = 4 µM). It increases adhesion and decreases de-adhesion of murine neutrophils, leading to reduced chemotaxis. It acts by reducing the rolling velocity of...
Keywords: | 4-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid |
Application: | Allosteric CD11b/CD18 activator |
CAS | 344897-95-6 |
MW: | 421.5 D |
From 82.00€
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Item number: Cay14825-250
Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans...
Keywords: | SQ 16,360, (4alpha,8alpha,9beta,13alpha,14beta)-16beta-(acetyloxy)-... |
Application: | Antibiotic |
CAS | 751-94-0 |
MW: | 538.7 D |
From 43.00€
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Item number: Cay14655-10
JWH 081 (Cay-10579) is a cannabimimetic aminoalkylindole that shows a high-affinity for the central cannabinoid (CB1) receptor with a Ki value of 1.2 nM and ten-fold reduced affinity for the peripheral cannabinoid (CB2) receptor (Ki = 12.4 nM). JWH 081-N-(cyclohexylmethyl) analog is a synthetic CB where a...
Keywords: | [1-(cyclohexylmethyl)-1H-indol-3-yl](4-methoxy-1-naphthalenyl)-methanone |
Application: | Analytical reference standard, Synthetic cannabinoid analog |
CAS | 1373876-34-6 |
MW: | 397.5 D |
From 291.00€
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Item number: Cay14625-1
Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1alpha (PGC-1alpha), regulates mitochondrial biogenesis and function. Expression of the membrane protein fibronectin...
Keywords: | Anti-FNDC5, Anti-FRCP2, Anti-Irisin, Anti-Fibronectin type III domain-containing protein 5, Anti-Fibronectin type III... |
Application: | ELISA, WB |
Host: | Rabbit |
564.00€
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Item number: Cay15625-25
Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM). It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with...
Keywords: | SCH 29851, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid, ethyl... |
Application: | Histamine H1 receptor antagonist |
CAS | 79794-75-5 |
MW: | 382.9 D |
From 60.00€
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Item number: Cay34658-25
Silychristin is a flavonolignan that has been found in S. marianum and has diverse biological activities. It inhibits monocarboxylate transporter 8 (MCT8, IC50 = ~100 nM) and MCT8-dependent uptake of the thyroid hormone 3,3',5-triiodo-L-thyronine (T3) in MDCK cells and primary mouse astrocytes (IC50s = 170 and 50...
Keywords: | (+)-Silychristin, Silychristin A,... |
Application: | Bioactive flavonolignan |
CAS | 33889-69-9 |
MW: | 482.4 D |
From 238.00€
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