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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay11069-100 | 100 µg | - |
6 - 10 business days* |
465.00€
|
|||
Cay11069-1 | 1 mg | - |
6 - 10 business days* |
3,238.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Bromodomain-containing 2 (BRD2) is a transcriptional regulator that is a member of the... more
Product information "BRD2 bromodomains 1 and 2 (human, recombinant)"
Bromodomain-containing 2 (BRD2) is a transcriptional regulator that is a member of the bromodomain and extra-terminal (BET) family. It is ubiquitously expressed and localizes to the nucleus. BRD2 is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple histone acetylation marks to the transcriptional regulation of target promoters, and an extra-terminal domain that mediates chromatin interactions. BRD2 associates with transcription effector and regulator proteins, including RNA polymerase II, histone acetylases and deacetylases, and transcriptional co-activators and co-repressors to form a transcription complex that regulates the expression of genes involved in inflammation and cell proliferation. BRD2 also binds to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein, a transmembrane protein involved in CoV virion assembly and pathogenesis of the related virus, SARS-CoV. siRNA knockdown of Brd2 reduces LPS-induced production of TNF and IL-6 in mouse bone marrow-derived macrophages (BMDMs). Genetic deletion of Brd2 in mice induces neural tube defects and is embryonic lethal. Brd2+/- mice have decreased numbers of GABAergic neurons and a reduced flurothyl-induced seizure threshold. SNPs in BRD2 have been found in individuals with juvenile myoclonic epilepsy. Cayman's BRD2 bromodomains 1 and 2 (human, recombinant) protein can be used for Western blot (WB) applications.Synonyms: Bromodomain containing protein 2, RING3, RNF3. Purity: >65% estimated by SDS-PAGE. Source: Recombinant GST-tagged protein expressed in E. coli. Amino Acids: 65-459. MW: 71.2 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 7.5, with 500 mM sodium chloride, 5% glycerol, and 5 mM beta-mercaptoethanol. UniProt Accession #: P25440.
Keywords: | BRD2, O27.1.1, O27.1.1, KIAA9001, Bromodomain-containing protein 2, Bromodomain-containing protein 2, Really interesting new gene 3 protein, Really interesting new gene 3 protein |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11069 |
Properties
Application: | Binding studies |
Conjugate: | No |
MW: | 71,2 kD |
Purity: | >65% estimated by SDS-PAGE |
Format: | Solution |
Database Information
KEGG ID : | K08871 | Matching products |
UniProt ID : | P25440 | Matching products |
Gene ID | GeneID 6046 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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