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DNA Methyltransferase 3L (human recombinant)
DNA Methyltransferase 3L (human recombinant)

Item number: Cay10770-25

The DNA methyltransferase 3 (DNMT3) family of DNMT proteins establish intial methylation of cytosines to form 5-methylcytosine at CpG (cytosine-phosphate-guanine) sites. Once methylation is established on DNA, DNMT1 protein is responsible for maintaining the CpG methylation pattern during chromosome replication. The...
Keywords: DNMT3L, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3-like
Application: Methylation studies
MW: 53,2 kD
732.00€ *
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AZD 1480
AZD 1480

Item number: Cay10702-5

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). AZD...
Keywords: 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Application: JAK2 inhibitor
CAS 935666-88-9
MW: 348.8 D
From 50.00€ *
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