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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay14167-100 | 100 µg | - |
6 - 10 business days* |
642.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The BRCA1 C-terminal (BRCT) domain is a modular unit of ~100 amino acids that folds independently... more
Product information "BRCA1 BRCT domains (human, recombinant)"
The BRCA1 C-terminal (BRCT) domain is a modular unit of ~100 amino acids that folds independently and recognizes linear phosphoserine or phosphothreonine regions to mediate protein-protein and protein-DNA interactions. BRCT domains were initially recognized in the C-terminal region of the breast cancer protein BRCA1, as well as the p53 binding protein (53BP1, TP53BP1), and the yeast cell cycle checkpoint protein RAD9. BRCT domains often occur as tandem repeats at the C-terminal end of several proteins that are functionally diverse. Most BRCT domain-containing proteins participate in DNA-damage checkpoint control or DNA-repair pathways, or both. Thus, BRCT domain-containing proteins likely participate in the cellular response to DNA damage. Germ-line mutations of the tumor suppressor genes BRCA1 and BRCA2 pre-dispose women to familial breast and ovarian cancer and are associated with approximately 10% of the cases. The carboxy-terminal BRCT domain in BRCA1 is involved in DNA repair and transcriptional activation. The BRCT region of BRCA1 binds phosphorylated BACH1, a DEAH helicase, which is essential for mediating repair of DNA double-strand breaks by controlling G2 to M phase transition during cell cycle progression. BRCA1 also contains an N-terminal protein-protein-interaction RING-finger domain, that partners with BRCA1-associated RING domain 1 (BARD1). The BRCA1/BARD1 heterodimer maintains genomic stability by regulating DNA damage repair and ubiquitination. This product contains the BRCT domains of BRCA1.Synonyms: Breast Cancer Type 1 Susceptibility Protein. Purity: >90% (estimated by SDS-PAGE). Source: Recombinant N-terminal GST-tagged protein expressed in E. coli. MW: 53.3 kDa. Formulation: (Request formulation change), 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride, and 20% glycerol. UniProt Accession #: P38398.
Keywords: | BRCA1, RNF53, RING finger protein 53, RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1, RING-type E3 ubiquitin transferase BRCA1, Breast cancer type 1 susceptibility protein, Breast cancer type 1 susceptibility protein |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14167 |
Properties
Application: | Binding assays |
Conjugate: | No |
Host: | E.coli |
MW: | 53,3 kD |
Purity: | >90% (estimated by SDS-PAGE) |
Format: | Solution |
Database Information
KEGG ID : | K10605 | Matching products |
UniProt ID : | P38398 | Matching products |
Gene ID | GeneID 672 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H315, H319, H372 |
P Phrases: | P260, P264, P270, P280, P302+352, P305+351+338, P314, P321, P332+313, P337+313, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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