BI-D1870

BI-D1870
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15264-1 1 mg -

6 - 10 business days*

76.00€
Cay15264-5 5 mg -

6 - 10 business days*

270.00€
Cay15264-10 10 mg -

6 - 10 business days*

431.00€
 
The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in... more
Product information "BI-D1870"
The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility. BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC50s = 31, 24, 18, and 15 nM, respectively). At 100 nM, it also significantly inhibits polo-like kinase 1, Aurora B, maternal embryonic leucine zipper kinase, and mammalian STE20-like kinase 2. BI-D1870 acts at the N-terminal kinase domain, but not the C-terminal domain, of RSK.Formal Name: 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridinone. CAS Number: 501437-28-1. Molecular Formula: C19H23F2N5O2. Formula Weight: 391.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 262, 296 nm. SMILES: OC1=C(F)C=C(NC2=NC(N(CCC(C)C)C(C)C(N3C)=O)=C3C=N2)C=C1F. InChi Code: InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24). InChi Key: DTEKTGDVSARYDS-UHFFFAOYSA-N.
Keywords: 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridinone
Supplier: Cayman Chemical
Supplier-Nr: 15264

Properties

Application: RSK1/2/3/4 inhibitor
MW: 391.4 D
Formula: C19H23F2N5O2
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 501437-28-1| Matching products
KEGG ID : K04373 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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