10 products were found matching "Cay11917-50"!

Diacerein is a prodrug form of the anthraquinone derivative rhein (Cay-17345). It inhibits RANKL- and IL-1beta-induced differentiation of RAW 264.7 cells into osteoclasts when used at a concentration of 20 µg/ml. Diacerein (20 µg/ml) reduces levels of interleukin-1beta-converting enzyme (ICE), also known as...

Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1, EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM). At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for...

4-Methylmethcathinone (also known as Mephedrone) is a stimulatory designer drug found in bath salts and similar products. Benzedrone is an analog of mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety. The physiological and toxicological properties of this compound are unknown....

Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 µM). It directly binds to SMO and can block SMO inhibition by cyclopamine. Binding of SAG alters the conformation of SMO, leading to its...

Salsalate is a non-steroidal anti-inflammatory drug (NSAID) and prodrug form of salicylic acid. It is converted to salicylic acid by hydrolysis. It inhibits prostaglandin E2 (PGE2, Cay-14010) production in isolated human whole blood stimulated with LPS (IC50 = 39.9 µM). Salsalate (1,000 mg/kg) inhibits weight gain...

AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 µM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.Formal Name: 4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime. CAS Number:...

Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-1 is a reactive disulfide-containing, fluorescent probe designed to detect H2S in biological samples and cells. Through a...

Substituted cathinones, including 4-methylmethcathinone (hydrochloride) (Cay-10801) and 4-methylethcathinone (hydrochloride) (Cay-9001069) are psychoactive compounds commonly used as recreational drugs. 4-Ethylethcathinone is a substituted cathinone with potential for abuse. Its physiological and toxicological...

JWH 412 is a positional isomer of AM2201 (Cay-10707) that was identified in the 'herbal mixture' XoXo. The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018. JWH 412...

PF-4800567 is a selective inhibitor of casein kinase 1epsilon (CK1epsilon, IC50 = 32 nM) with greater than 20-fold selectivity over CK1delta. It blocks CK1epsilon-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells. PF-4800567 has...