4 products were found matching "Cay11917-25"!
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CC-223
Item number: Cay19917-25
CC-223 is a potent inhibitor of mTOR (IC50 = 16 nM) that shows selectivity for mTOR over a panel of 246 other kinases. It blocks signaling through both mTORC1 and mTORC2, inhibiting the phosphorylation of S6RP, 4EBP1, and Akt(S473) in cellular systems. CC-223 inhibits growth and induces apoptosis in hematologic and...
| Keywords: | 3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)-pyrazino[2,3-b]pyrazin-2(1H)-one |
| Application: | mTOR inhibitor |
| CAS | 1228013-30-6 |
| MW: | 397.5 D |
From 66.00€
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CP 724,714
Item number: Cay19172-5
CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met. CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50...
| Keywords: | 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide |
| Application: | ErbB2 inhibitor |
| CAS | 383432-38-0 |
| MW: | 469.5 D |
From 50.00€
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WZ4003
Item number: Cay19177-25
NUAK1 (also known as AMPK-related kinase 5) and NUAK2 (also known as SNF1/AMPK-related kinase) are members of the AMP-activated protein kinase (AMPK) family of protein kinases that are activated by the liver kinase B1 tumor suppressor kinase. NUAK kinases are thought to have roles in regulating cell adhesion, cancer...
| Keywords: | N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-propanamide |
| Application: | Selective NUAK1 / NUAK2 inhibitor |
| CAS | 1214265-58-3 |
| MW: | 497 D |
From 43.00€
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Edaglitazone
Item number: Cay19117-25
Edaglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma). It activates PPARgamma in a reporter assay using CV-1 cells expressing murine PPARgamma2 when used at concentrations ranging from 0.1 to 1 µM. Edaglitazone (1, 5, and 25 µM) increases [3H]2-deoxyglucose transport in the...
| Keywords: | BM 13.1258, 5-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione |
| Application: | PPARgamma agonist |
| CAS | 213411-83-7 |
| MW: | 464.6 D |
From 145.00€
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