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BAY u9773 is a cysteinyl leukotriene 1 (CysLT1) and CysLT2 receptor antagonist. It inhibits contractions induced by leukotriene D4 (LTD4, Cay-20310) or LTC4 (Cay-20210) in isolated guinea pig trachea, rat lung, ferret spleen, and sheep bronchus (pA2s = 6.8-7.4). BAY u9773 (0.1 mg/kg) suppresses airway hypersensitivity and bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a guinea pig model of ovalbumin-induced asthma. It also increases the latency to generalized seizures and decreases the EEG amplitude in a mouse model of seizures induced by pentylenetetrazol (PTZ, Cay-18682).Formal Name: 4-[[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraenyl]thio]-benzoic acid. CAS Number: 154978-38-8. Molecular Formula: C27H36O5S. Formula Weight: 472.6. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): .15 mg/ml. lambdamax: 279 nm. SMILES: CCCCC/C=C\C\C=C/C=C\C=C/[C@@H](Sc1ccc(cc1)C(=O)O)C(O)CCCC(=O)O. InChi Code: InChI=1S/C27H36O5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(28)15-14-17-26(29)30)33-23-20-18-22(19-21-23)27(31)32/h6-7,9-13,16,18-21,24-25,28H,2-5,8,14-15,17H2,1H3,(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t24-,25+/m0/s1. InChi Key: PKJINWOACFYDQN-RBVMPENBSA-N.
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