Ramatroban

Ramatroban
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10156-1 1 mg -

6 - 10 business days*

43.00€
Cay10156-5 5 mg -

6 - 10 business days*

129.00€
Cay10156-10 10 mg -

6 - 10 business days*

222.00€
Cay10156-50 50 mg -

6 - 10 business days*

998.00€
 
Ramatroban is a dual TP and DP2/CRTH2 receptor antagonist (Kis = 4.5 and 4.3 nM for the human... more
Product information "Ramatroban"
Ramatroban is a dual TP and DP2/CRTH2 receptor antagonist (Kis = 4.5 and 4.3 nM for the human receptors, respectively). It is selective for these receptors over the prostaglandin E2 (PGE2) receptor subtypes EP1 and EP2, as well as the FP and IP receptors, at 1 µM. Ramatroban inhibits contractions induced by U-46619 (Cay-16450) or PGD2 (Cay-12010) in isolated guinea pig tracheal rings (pA2s = 8.7 and 8.6, respectively). It also reduces PGD2-induced migration of isolated human eosinophils when used at concentrations of 1, 10, and 100 nM. Ramatroban (5 mg/kg) inhibits ovalbumin-induced airway eosinophil infiltration and mucus cell hyperplasia in an ovalbumin-sensitized mouse model of asthma. Formulations containing ramatroban have been used in the treatment of allergic rhinitis.Formal Name: 3R-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid. CAS Number: 116649-85-5. Synonyms: Bay u3405. Molecular Formula: C21H21FN2O4S. Formula Weight: 416.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 228, 285 nm. SMILES: O=S(N[C@H](CC1)CC2=C1N(CCC(O)=O)C3=CC=CC=C23)(C4=CC=C(F)C=C4)=O. InChi Code: InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1. InChi Key: LDXDSHIEDAPSSA-OAHLLOKOSA-N.
Keywords: Ramatroban, 3R-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
Supplier: Cayman Chemical
Supplier-Nr: 10156

Properties

Application: DP2 receptor antagonist
MW: 416.5 D
Formula: C21H21FN2O4S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 116649-85-5| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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