Atipamezole is an antagonist of alpha2A-adrenergic receptors (alpha2A-ARs, Ki = 1.86 nM). It is selective for alpha2A-ARs over alpha2B- and alpha1-ARs (Kis = 1,949.83 and 13,300 nM, respectively), as well as over 40 receptors, ion channels, and transporters (IC50s = 540->10,000 nM). Atipamezole (0.04, 0.08, and 1.2...

(±)-O-Desmethyl venlafaxine is an active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP2D6. Desvenlafaxine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with IC50...

UK 122 is an inhibitor of urokinase-type plasminogen activator (uPA, IC50 = 0.2 µM). It is selective for uPA over tissue-type plasminogen activator (tPA), trypsin, plasmin, and thrombin (IC50s = >100 µM for all). UK 122 (100 µM) inhibits the migration and invasion of CFPAC-1 pancreatic cancer cells. It prevents...

Docosahexaenoyl ethanolamide-d4 contains four deuterium atoms at the 1, 1', 2, and 2' positions. It is intended for use as an internal standard for the quantification of docosahexaenoyl ethanolamide by GC- or LC-mass spectrometry (MS). Docosahexaenoic Acid (DHA) is an essential fatty acid and the most abundant...

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2). It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of...