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You can also order by e-mail: info@biomol.com
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Apocynin is an acetophenone originally isolated from P. kurroa that has antioxidant and... more
Product information "Apocynin"
Apocynin is an acetophenone originally isolated from P. kurroa that has antioxidant and anti-inflammatory activities. It inhibits glucose production in H-4-II-E-C3 cells (IC50 = 25 µM). Apocynin inhibits the production of superoxide anions induced by PMA (Cay-10008014) in isolated human leukocytes in a concentration-dependent manner. It increases nitric oxide (NO) bioavailability in rat carotid arterial rings isolated from spontaneously hypertensive stroke-prone (SHRSP) rats when used at concentrations of 0.3 or 3 mM. Apocynin (5 mg/kg) reduces lung injury and pulmonary TNF-alpha and IL-1beta levels in a mouse model of pleurisy induced by carrageenan. It inhibits IkappaBalpha degradation and reduces NF-kappaB p65 and inducible nitric oxide synthase (iNOS) protein levels in the same model. Formulations containing apocynin have been used in the treatment of rheumatoid arthritis, osteoarthritis, bronchial asthma, and chronic obstructive pulmonary disease (COPD).Formal Name: 1-(4-hydroxy-3-methoxyphenyl)-ethanone. CAS Number: 498-02-2. Synonyms: Acetoguaiacone, Acetovanillone, NSC 2146, NSC 209524. Molecular Formula: C9H10O3. Formula Weight: 166.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 229, 276, 304 nm. SMILES: CC(C1=CC(OC)=C(O)C=C1)=O. InChi Code: InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3. InChi Key: DFYRUELUNQRZTB-UHFFFAOYSA-N.
Keywords: | Acetoguaiacone, Acetovanillone, NSC 209524, NSC 2146, 1-(4-hydroxy-3-methoxyphenyl)-ethanone |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11976 |
Properties
Application: | NADPH oxidase inhibitor |
MW: | 166.2 D |
Formula: | C9H10O3 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 498-02-2| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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