Apigenin

Apigenin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010275-25 25 mg -

6 - 10 business days*

82.00€
Cay10010275-50 50 mg -

6 - 10 business days*

150.00€
Cay10010275-100 100 mg -

6 - 10 business days*

284.00€
Cay10010275-500 500 mg -

6 - 10 business days*

1,247.00€
 
Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits... more
Product information "Apigenin"
Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the degradation of IkappaBalpha and down-regulates NF-kappaB levels in WEHI-231 cells. Apigenin at 5 µM is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.Formal Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 520-36-5. Synonyms: Chamomile, Flavone, NSC 83244, Versulin. Molecular Formula: C15H10O5. Formula Weight: 270.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 15 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 212, 269, 334 nm. SMILES: Oc1ccc(cc1)c1cc(=O)c2c(O)cc(O)cc2o1. InChi Code: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H. InChi Key: KZNIFHPLKGYRTM-UHFFFAOYSA-N.
Keywords: Chamomile, Flavone, NSC 83244, Versulin, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Supplier: Cayman Chemical
Supplier-Nr: 10010275

Properties

Application: CK2 inhibitor
MW: 270.2 D
Formula: C15H10O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 520-36-5| Matching products
KEGG ID : K03097 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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