12 products were found matching "Cay10004872"!

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM. 12(S)-HETE MaxSpec(R) standard is a quantitative grade standard of 12(S)-HETE (Cay-34570) that has been prepared specifically for...

Sulindac sulfide is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor sulindac (Item No, 10004386). It inhibits both COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively), whereas the parent compound, sulindac, is much less effective (IC50 = 58 µM for COX-2 and > 100 µM for...

(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (-)-nutlin-3 (Cay-18585) and its less active enantiomer (+)-nutlin-3 (Cay-10009816). In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.Formal Name:...

Formulation: A lyophilized powder.

Formulation: A lyophilized powder.

1-Stearoyl-2-arachidonoyl-d8-sn-glycerol (SAG-d8) is intended for use as an internal standard for the quantification of SAG (Cay-10008650) by GC- or LC-MS. Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid in order to...

Peroxisome proliferator-activated receptor delta (PPARdelta) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity. GW 501516 is the first highly selective synthetic PPARdelta agonist available. GW 501516 binds to human PPARdelta...

CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 µM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight...

Lubiprostone is an activator of chloride channel protein 2 (ClC-2) and a bicyclic derivative of prostaglandin E1 (PGE1, Cay-13010). It induces chloride currents in HEK293 cells expressing recombinant human ClC-2 (EC50 = ~17 nM), but not CFTR, chloride channels. Lubiprostone (1 µM) induces short-circuit currents, a...

Synonyms: 2-thio PAF (substrate), 2-Thio PAF PAF-AH Inhibitor Screening (substrate), 2-Thio PAF PAF-AH (substrate).

Formulation: A solution of 95 uM Arg-Glu(EDANS)-Ile_his-Pro-Phe-His-Leu-Val-Ile-His-Lys(Dabvyl)-Arg in dimethyl sulfoxide.

Ursolic acid is a pentacyclic triterpenoid that has been isolated from M. pumila and has diverse biological activities, including anticancer, hepatoprotective, anti-inflammatory, antioxidant, antimicrobial, and cardioprotective properties. It inhibits the proliferation of HepG2 liver, MCF-7 breast, and Caco-2 colon...