Anti-phospho-SMC1 (Ser957)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A304-147A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A304-147A	100 µl (100 µg)		-		2 - 8 business days*		626.00€

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Protein function: Involved in chromosome cohesion during cell cycle and in DNA repair. Central... more

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Product information "Anti-phospho-SMC1 (Ser957)"

Protein function: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. [The UniProt Consortium]

Keywords:	Anti-phospho-SMC1A, Anti-phospho-Sb1.8, Anti-phospho-SMC-1A, Anti-phospho-DXS423E, Anti-phospho-SMC-1-alpha, Anti-phospho-SMC protein 1A, Anti-phospho-Structural maintenance of chromosomes protein 1A
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-147A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: bovine)
Immunogen:	synthetic peptide. The epitope recognized by A304-147A maps to a region of human SMC1 (structural maintenance of chromosomes 1-like 1 ) surrounding serine 957 using the numbering given in entry NP_006297.2 (Gene ID 8243) when the serine residue is phosphorylated.
Format:	Antigen Affinity Purified