Anti-Progesterone Receptor (Phospho-Ser190)

Anti-Progesterone Receptor (Phospho-Ser190)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009762-1 1 each -

6 - 10 business days*

564.00€
 
There is accumulating evidence to suggest that progesterone plays an essential role in the... more
Product information "Anti-Progesterone Receptor (Phospho-Ser190)"
There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.Immunogen: Phosphopeptide from amino acid residues surrounding the phospho-Ser294 of human progesterone receptor. Clone Designation: 1154. MW: 90/120 kDa. Formulation: (Request formulation change), 100 µl of protein G-affinity purified monoclonal antibody. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 mM sodium chloride, 100 µg/ml BSA, and 50% glycerol. Host: Mouse. Isotype: IgG1. Applications: IHC, WB. Origin: Animal/Mouse.
Keywords: Anti-phospho-PR, Anti-phospho-PGR, Anti-phospho-NR3C3, Anti-phospho-Progesterone receptor, Anti-phospho-Nuclear receptor subfamily 3 group C member 3 (pS190)
Supplier: Cayman Chemical
Supplier-Nr: 10009762

Properties

Application: WB, IHC (frozen)
Antibody Type: Monoclonal
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor
Format: Solid

Database Information

KEGG ID : K08556 | Matching products
UniProt ID : P06401 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H316, H319
P Phrases: P264, P280, P305+351+338, P332+313, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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