Anti-GluR1 (Phospho-Ser831)

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CaM kinase II. In addition, phosphorylation of this site has been linked to synaptic plasticity as well as learning and memory.Synonyms: Glutamate Receptor Subunit 1. Immunogen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser831 of GluR1. Formulation: (Request formulation change), Affinity-purified IgG. Host: Rabbit. Applications: WB. Origin: Animal/Rabbit.