Anti-phospho-Estrogen Receptor, (S118) (ER, ER-alpha, Estradiol Receptor, Nuclear Receptor Subfamil

Anti-phospho-Estrogen Receptor, (S118) (ER, ER-alpha, Estradiol Receptor, Nuclear Receptor Subfamil
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E3564-75A.100 100 µg - -

3 - 19 business days*

843.00€
 
ER alpha (Estrogen receptor alpha, also Estradiol receptor and NR3A1) is a 65-70kD member of the... more
Product information "Anti-phospho-Estrogen Receptor, (S118) (ER, ER-alpha, Estradiol Receptor, Nuclear Receptor Subfamil"
ER alpha (Estrogen receptor alpha, also Estradiol receptor and NR3A1) is a 65-70kD member of the NR3 subfamily, nuclear hormone receptor family of proteins. It is widely expressed, and serves as a strong activator of estrogen-responsive genes. ER-a is normally quiescent and bound to heat-shock proteins and immunophilins. Following b-estradiol binding, it becomes activated, either homodimerizes or heterodimerizes with ER-b, and binds to DNA with multiple co-activators. Major phosphorylation sites exist at Tyr537, Ser167 and Ser118. Phosphorylation at Ser118 regulates ER-alpha's role in transcription and cell growth. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-phospho-Estrogen receptor, Anti-phospho-Estradiol receptor, Anti-phospho-Nuclear receptor subfamily 3 group A member 1
Supplier: United States Biological
Supplier-Nr: E3564-75A

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding S118 of human ER alpha (Accession # P03372).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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