Anti-phospho-p53 (Thr18) (Cellular Tumor Antigen p53, Tumor Suppressor p53, Phosphoprotein p53, Anti

Anti-phospho-p53 (Thr18) (Cellular Tumor Antigen p53, Tumor Suppressor p53, Phosphoprotein p53, Anti
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P1001-27L3-APC.200 200 µl - -

3 - 19 business days*

993.00€
 
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle,... more
Product information "Anti-phospho-p53 (Thr18) (Cellular Tumor Antigen p53, Tumor Suppressor p53, Phosphoprotein p53, Anti"
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Applications: Suitable for use in FLISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Supplier: United States Biological
Supplier-Nr: P1001-27L3-APC

Properties

Application: FLISA, Dot Blot, IHC, WB
Antibody Type: Polyclonal
Conjugate: APC
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr18 of human p53 (KLH).
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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