The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (2,3). DNA...

Fusion Partners: Spleen cells from immunized BALB/c mice were fused with cells of the mouse X63Ag8.653 myeloma cell line. Recommended Negative Controls: Mouse IgM Negative Control , Applications:, Flow Cytometry: Neat., use 10ul to label 10ee6 cells or 100ul whole blood. Membrane permeabilization is required. ,...

The tumor suppressor protein, p53, is expressed ubiquitously and plays an important role in blocking proliferation of damaged cells. Phosphorylation of p53 at serine 392 is reported in response to diverse stresses, for example UV irradiation. The specificity of this antibody has been shown by blocking studies in...