The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (2,3). DNA...

P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability....

Applications:, Suitable for use in ELISA, Immunoflourescence, Immunohistochemistry, Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunohistochemistry: frozen sections, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for...