Fusion Partners: Spleen cells from immunized BALB/c mice were fused with cells of the mouse X63Ag8.653 myeloma cell line. Recommended Negative Controls: Mouse IgM Negative Control , Applications:, Flow Cytometry: Neat., use 10ul to label 10ee6 cells or 100ul whole blood. Membrane permeabilization is required. ,...

P53 is a 339 amino acid protein (53kD) that is thought to act as a tumor suppressor gene. p53 is a DNA-binding protein, and missense mutation of the gene can lead to loss of its DNA-binding functions, and subsequent inactivation of p53 may be a contributing factor in tumorigenesis. Mutation of p53 occurs at many...

The p53 gene is located on human chromosome 17p13.1. Mutation and/or allelic loss of this gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. P53 binds to a DNA consensus sequence, the p53 response element, and it...

Human p53 is a tumor suppressor protein which is mutated in many cancers. p53 expression has been linked to apoptosis caused by DNA-damaging agents and may have a role in cell-mediated cytotoxicity. Applications: Suitable for use in Western Blot, Flow Cytometry and Immunohistochemistry. Other applications not...

p53 is a 53kD protein that forms tetramers and functions as a tumor suppressor and transcriptional activator of genes that inhibit growth and/or invasion, cell cycle checkpoint after irradiation, DNA repair, apoptotic induction, signal transduction, and cell adhesion. This protein is localized to the nucleus when...