Anti-p130 (Rb2)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
100-401-173	100 µl		-	-	6 - 10 business days*		684.00€

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Protein function: Key regulator of entry into cell division. Directly involved in heterochromatin... more

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Product information "Anti-p130 (Rb2)"

Protein function: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. [The UniProt Consortium]

Keywords:	Anti-RB2, Anti-p130, Anti-RBL2, Anti-pRb2, Anti-RBR-2, Anti-Retinoblastoma-like protein 2, Anti-Retinoblastoma-related protein 2, Anti-130 kDa retinoblastoma-associated protein
Supplier:	Rockland Immunochemicals
Supplier-Nr:	100-401-173

Properties

Application:	ELISA, IHC, IP, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, rat, mouse
Immunogen:	Rb2 (p130) peptide corresponding to a region near the C-terminus of the human protein
MW:	130 kD
Format:	Antiserum