Anti-eIF4AIII/EIF4A3

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-980A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A302-980A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: ATP-dependent RNA helicase. Core component of the splicing-dependent... more
Product information "Anti-eIF4AIII/EIF4A3"
Protein function: ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly. Involved in craniofacial development. [The UniProt Consortium]
Keywords: Anti-DDX48, Anti-EIF4A3, EC=3.6.4.13
Supplier: Bethyl Laboratories
Supplier-Nr: A302-980A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine, pig)
Immunogen: synthetic peptide. The epitope recognized by A302-980A maps to a region between residue 1 and 50 of human Eukaryotic Translation Initiation Factor 4A3 using the numbering given in entry NP_055555.1 (GeneID 9775).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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