Anti-Thromboxane B2 11-dehydrogenase Antiserum

Aldehyde dehydrogenase (ALDH) is an enzyme that catalyzes the oxidation of various aldehydes to their corresponding carboxylic acid. There are 19 human ALDH isozymes, which have varying expression levels, subcellular localization, tissue distribution, cofactor preference, and substrate specificity. ALDH exists as a homodimer or homotetramer and is composed of a cofactor-binding domain, which binds NAD+ or NADP+, a catalytic domain, and an oligomerization domain. ALDH has protective roles in alcohol detoxification and oxidative stress, regulatory roles in the function of normal stem cells and tumor-initiating stem-like cells, and a biosynthetic role in the formation of retinoic acid. It also catalyzes the catabolism of thromboxane B2 (TXB2, Cay-19030) to 11-dehydro TXB2 (Cay-19500). Mutations in the genes encoding ALDH isozymes are associated with a variety of human conditions, including alcohol intolerance, Parkinson's disease, and gout. Cayman's Aldehyde Dehydrogenase Polyclonal Antiserum can be used for Western blot (WB) applications. The antibody recognizes ALDH at 55 kDa from human and mouse samples.Synonyms: ALDH1, Retinal Aldehyde Dehydrogenase, Thromboxane B2 11-dehydrogenase, TXB2 11-dehydrogenase. Immunogen: Human erythrocyte ALDH. MW: 55 kDa. Formulation: (Request formulation change), Polyclonal antiserum. Storage Buffer: Polyclonal antiserum when reconstituted in 100 µl deionized water. Host: Rabbit. Applications: WB. Cross Reactivity: (+) ALDH. Origin: Animal/Rabbit.