Anti-TRAF2

Anti-TRAF2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-460A-T 10 µl (2 µg) -

2 - 8 business days*

164.00€
A303-460A 100 µl -

2 - 8 business days*

588.00€
 
Protein function: Regulates activation of NF-kappa-B and JNK and plays a central role in the... more
Product information "Anti-TRAF2"
Protein function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. [The UniProt Consortium]
Keywords: Anti-TRAP3, Anti-TRAF2, EC=6.3.2.-, Anti-TNF receptor-associated factor 2, Anti-E3 ubiquitin-protein ligase TRAF2, Anti-Tumor necrosis factor type 2 receptor-associated protein 3
Supplier: Bethyl Laboratories
Supplier-Nr: A303-460A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: chicken, orangutan, rhesus monkey, gorilla, chimpanzee, duckbill platypus, african elephant, naked mole rat)
Immunogen: synthetic peptide. The epitope recognized by A303-460A maps to a region between residue 175 and 225 of human TNF receptor-associated factor 2 using the numbering given in entry NP_066961.2 (GeneID 7186).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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