Anti-THYMIDYLATE SYNTHASE

Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-601-199-0100 100 µg - -

6 - 10 business days*

684.00€
 
Anti-THYMIDYLATE SYNTHASE IgG fraction is directed against human Thymidylate Synthase and is... more
Product information "Anti-THYMIDYLATE SYNTHASE"
Anti-THYMIDYLATE SYNTHASE IgG fraction is directed against human Thymidylate Synthase and is useful in determining its presence in various assays.  Because inhibition of Thymidylate Synthase prevents DNA synthesis and cell proliferation, the enzyme is an important target for cancer chemotherapeutic drugs, specifically the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors.  In general, this antibody can detect antigen in a variety of human cells and tissues, as well as bacteria, African green monkey, rat and mouse.  Somewhat lower dilutions may be required in some non-human cell lines.   Anti-Thymidylate Synthase can detect Thymidylate Synthase by immunochemistry in proliferating cell cultures and tissues but does not stain nonproliferating cells.  Normal colon mucosa shows weak staining. however, some colorectal cancer specimens show very strong staining. Protein function: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. [The UniProt Consortium]
Keywords: Anti-TS, Anti-TYMS, Anti-TSase, EC=2.1.1.45, Anti-Thymidylate synthase
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-601-199-0100

Properties

Application: ELISA, IHC, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Sheep
Species reactivity: human
Immunogen: recombinant human Thymidylate Synthase (36 kDa) produced in E.coli.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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