10 products were found matching "BPS-25318"!

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed...

RbAp48 (UniProtKB/Swiss Prot entry Q09028) is a component of several complexes which regulate chromatin metabolism. These include (1) the chromatin assembly factor 1 (CAF 1) complex, which is required for chromatin assembly following DNA replication and DNA repair, (2) the core histone deacetylase (HDAC) complex,...

Set9 (UniProtKB/Swiss Prot entry Q8WTS6) is a histone methyltransferase which specifically methylates lysine 4 of histone H3 being a specific tag for epigenetic transcriptional activation. Further, methylation of histone H3K4 by Set9 precludes deacetylation of H3 by the NuRD complex and impairs Suv39h1 mediated...

SETD1A (UniProt/Swiss Prot entry O15047) is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional...

SETD1B (UniProt/Swiss Prot entry Q9UPS6) is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional...

SETD8 (UniProtKB/Swiss Prot entry Q9NQR1) is a histone methyl transferase that specifically monomethylates Lys 20 of histone H4. This histone modification represents a specific tag for epigenetic transcriptional repression en is enriched during mitosis. SETD8 may also play a role in maintaining silent chromatin by...

SirT1 (UniProtKB/Swiss Prot entry Q96EB6) is a NAD dependent deacetylase, which regulates processes such as apoptosis and muscle differentiation by the deacetylation of key regulatory proteins. Deacetylation of lysine 382 of p53/TP53 by Sirt1 impairs its ability to induce the proapoptotic program and modulate cell...

TATA binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found approximately 30 base pairs upstream of the transcription start site in 10 20% of eukaryotic gene promoters. TBP is a subunit of the eukaryotic transcription factor TFIID....

DNMT3A (UniProtKB/Swiss Prot entry Q9Y6K1) catalyses the genome wide de novo methylation of CpG residues. DNA methylation on CpG residues by DNMT3A regulates gene expression and is essential for development. DNMT3A is strongly expressed in embryonic stem cells, but low in adult somatic cells. DNA methylation is...

PHD finger protein 8 (UniProtKB/Swiss Prot entry Q9UPP1) is a jumonji domain containing protein. Like other members of the jumonji family, PHF8 may therefore play a role in histone demethylation. Mutations in PHF8 lead to Siderius type X linked mental retardation (MRXSSD), a mild to borderline type of mental...