Guanabenz is an alpha2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects. It also competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM).Formal Name: 2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide, monohydrochloride. CAS Number: 23113-43-1....

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is...

The 15-deoxy-Delta12,14-prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) Quant-PAK has been designed for the convenient, precise quantification of 15-deoxy-Delta12,14-PGJ2 by GC- or LC-mass spectrometry. It includes a 50 µg vial of 15-deoxy-Delta12,14-PGJ2-d4 and a precisely weighed vial of unlabeled...

Stearidonic acid (18:4omega-3) is a rare polyunsaturated fatty acid of the omega-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. It is present in certain natural oils such as echium and black currant seed, and to the extent that these oils are incorporated into...

9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxo ODA) is a natural agonist, abundant in tomatoes, that activates PPARalpha at 10-20 µM. It is produced from conjugated linoleic acid, which is also known to be a PPARalpha agonist. 9-oxo ODA increases the expression of genes regulated by PPARalpha in primary mouse...