29 products were found matching "S1014A-01R.50"!

SLITRK5 (Slit and Trk-like family member 5, also LRR-containing protein 11) is a member of the SLITRK family of proteins. This family currently includes six members, all of which contain a slit-like extracellular region and (save for SLITRK1) a Trk-like cytoplasmic region. Human SLITRK5 is a type I transmembrane...

SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are...

Slit1 is a member of the Slit family of large secreted axon guidance molecules that are ligands for Robo receptors (1, 2). Like other mammalian family members, the 1534aa, ~200kD human Slit1 contains a 33aa signal sequence followed by 23 leucine-rich repeats (LRR, aa34-900) and 9 EGF-like sequences (aa930-1454) (2)....

KCNN3 forms one of several calcium-activated potassium channels which are activated in a voltage-independent manner and have a relatively small unit conductance and high sensitivity to intracellular calcium. Activation is followed by membrane hyperpolarization. It is thought to regulate neuronal excitability by...

Slit proteins are ligands at the Roundabout (Robo) receptors and act as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate...

Slit-2 is thought to act as molecular guidance cue in cellular migration, and its function appears to be mediated by interaction with roundabout homolog (ROBO) receptors. It is a secreted protein known for its role of repulsion in axon guidance and neuronal migration that can also inhibit leukocyte chemotaxis...

Smad proteins have been implicated as downstream effectors of TGF beta/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF beta and activin mediated growth modulation. Smad4 has been shown to mediate all of the above activities through interaction...

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional...

SMAD2 protein (also known as MADH2) is a transcriptional modulator activated by TGF beta. It is found at high levels in skeletal muscle, heart and placenta. SMAD2 exists in isoforms, a predominant long form and a short form missing the 30aa exon 3. The short form shows DNA binding and higher transcriptional...

Applications:, Suitable for use in ELISA, Immunofluorescence, Western Blot and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry: 2.5ug/ml, Western Blot: 1:2000-1:20,000, ELISA: 1:25,000-1:100,000, Optimal dilutions to be determined by the researcher....

Smad3 is a 50kD transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase, functioning in cell proliferation, differentiation and development. Upon stimulation, Smad3 oligomerizes with Smad4 and translocates into the nucleus and binds to DNA and transcription factors. Smad3 activity induces...

SNAP43 is part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. It binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. SNAP43 Recruits TBP and BRF2 to the U6 snRNA TATA box. Applications:...