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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
100-401-V82 | 100 µl | - | - |
6 - 10 business days* |
641.00€
|
Anti-SETD8 Antibody is monospecific antiserum processed by delipidation and defibrination... more
Product information "Anti-SETD8"
Anti-SETD8 Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. Cross reactivity with SETD8 from species other than human and mouse not tested. Protein function: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [The UniProt Consortium]
Keywords: | Anti-SETD8, Anti-KMT5A, Anti-PR-Set7, Anti-PR/SET07, EC=2.1.1.-, EC=2.1.1.43, Anti-H4-K20-HMTase SETD8, Anti-Lysine N-methyltransferase 5A, Anti-SET domain-containing protein 8, Anti-N-lysine methyltransferase SETD8, Anti-PR/SET domain-containing protein |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 100-401-V82 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | The full length human SETD8 protein containing a Flag-tagged N-terminus and a His-tagged C terminus. |
Format: | Antiserum |
Database Information
KEGG ID : | K11428 | Matching products |
UniProt ID : | Q9NQR1 | Matching products |
Gene ID | GeneID 387893 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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