Anti-SETD8

Anti-SETD8
Item number Size Datasheet Manual SDS Delivery time Quantity Price
100-401-V82 100 µl - -

6 - 10 business days*

641.00€
 
Anti-SETD8 Antibody is monospecific antiserum processed by delipidation and defibrination... more
Product information "Anti-SETD8"
Anti-SETD8 Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. Cross reactivity with SETD8 from species other than human and mouse not tested. Protein function: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [The UniProt Consortium]
Keywords: Anti-SETD8, Anti-KMT5A, Anti-PR-Set7, Anti-PR/SET07, EC=2.1.1.-, EC=2.1.1.43, Anti-H4-K20-HMTase SETD8, Anti-Lysine N-methyltransferase 5A, Anti-SET domain-containing protein 8, Anti-N-lysine methyltransferase SETD8, Anti-PR/SET domain-containing protein
Supplier: Rockland Immunochemicals
Supplier-Nr: 100-401-V82

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: The full length human SETD8 protein containing a Flag-tagged N-terminus and a His-tagged C terminus.
Format: Antiserum

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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