Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Immunogen: synthetic peptide
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Manual
Kat #: ABD-8B8059.50
Menge: 50 µgBuy Bulk
Preis: 195 €
UniProt ID: P06400 (Protein knowledgebase)
Geninformationen: GeneID 5925
Passende, verwandte Produkte
Antikörper-Konjugations-Kits
Schlagworte:
Anti-Rb, Anti-pRb, Anti-RB1, Anti-pp110, Anti-p105-Rb, Anti-Retinoblastoma-associated protein, antibody, antibodies, Antikörper Loading ...
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| Weitere Produkte für dieses Protein:Antibodies
- Anti-phospho-Rb (Ser249), Kat #: WA-AP3233a
- Anti-phospho-Rb (Ser249), Kat #: WA-AP3233a.20
- Anti-phospho-RB (Ser608), Kat #: WA-AP3235a.20
- Anti-phospho-RB (Ser608), Kat #: WA-AP3235a
- Anti-phospho-RB (Ser612), Kat #: WA-AP3236a.20
- Anti-phospho-RB (Ser612), Kat #: WA-AP3236a
- Anti-phospho-Rb (Ser780), Kat #: WA-AP3237a.20
- Anti-phospho-Rb (Ser780), Kat #: WA-AP3237a
- Anti-phospho-Rb (Ser780), Kat #: WA-AJ1682b
- Anti-phospho-Rb (Ser788), Kat #: WA-AP3238a.20
- more
Enzymes & Proteins
siRNA
Primers
Peptides
- Phospho-Rb-S249 Antibody Blocking Peptide, Kat #: WA-BP3233a
- Phospho-RB-S608 Antibody Blocking Peptide, Kat #: WA-BP3235a
- Phospho-RB-S612 Antibody Blocking Peptide, Kat #: WA-BP3236a
- Phospho-Rb-S780 Antibody Blocking Peptide, Kat #: WA-BP3237a
- Phospho-Rb-S788 Antibody Blocking Peptide, Kat #: WA-BP3238a
- Phospho-RB-S795 Antibody Blocking Peptide, Kat #: WA-BP3239a
- Phospho-Rb-T826 Antibody Blocking Peptide, Kat #: WA-BP3244a
- PhosphoRb-S811 Antibody Blocking Peptide, Kat #: WA-BP3241a
- RB1 Antibody (C-term) Blocking Peptide, Kat #: WA-BP8575b
- RB1 Antibody (S608) Blocking Peptide, Kat #: WA-BP6265e
Products for: RB1 - retinoblastoma-associated protein
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