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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10011436-25 | 25 µg | - |
6 - 10 business days* |
324.00€
|
|||
Cay10011436-100 | 100 µg | - |
6 - 10 business days* |
530.00€
|
Postsynaptic Density protein 95 (PSD95), also known as synapse associated protein 90 kDa, is a... more
Product information "Anti-PSD95 (Clone 7E3)"
Postsynaptic Density protein 95 (PSD95), also known as synapse associated protein 90 kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex. These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domains localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. PSD95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins. Thus different PDZ domains of PSD95 might be specialized for distinct functions. PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs). The protein is implicated in experience-dependent plasticity and plays an indispensable role in learning. Mutations in PSD95 are associated with autism.Synonyms: Postsynaptic Density Protein 95. Immunogen: Rat recombinant PSD95. Clone Designation: 7E3. Formulation: (Request formulation change), 25 or 100 µg of protein G-affinity purified monoclonal antibody. Storage Buffer: PBS, pH 7.4, with 50% glycerol and 0.09% sodium azide. Host: Mouse. Isotype: IgG2a. Applications: ICC, IF, IHC, WB. UniProt Accession #: P31016. Origin: Animal/Mouse.
Keywords: | Postsynaptic Density Protein 95 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10011436 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 7000 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | rat |
Immunogen: | rat recombinant PSD95 |
Format: | Solid |
Database Information
KEGG ID : | K11828 | Matching products |
UniProt ID : | P31016 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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