11 products were found matching "P4070-76G.100"!

Reacts with the novel (plant homeodomain)/ LAP (leukemia-associated protein) PHD ?nger protein PHF-2. PHF-2 is widely expressed and is implicated in hereditary sensory neuropathy type 1 HSN1. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. Recommended Dilution:...

This antibody reacts with the novel (plant homeodomain)/LAP (leukemia-associated protein) PHD finger protein PHF-2. PHF-2 is widely expressed and is implicated in hereditary sensory neuropathy type 1 (HSN1). Positive Control: Placenta lysate , Applications: , Suitable for use in Western Blot. Other applications not...

PHF-2 is widely expressed and is implicated in hereditary sensory neuropathy type 1 HSN1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For...

PHLPPL (PH domain leucine-rich repeat-containing protein phosphatase-like) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPPL has been demonstrated to trigger apoptosis and...

PHLPP1 is the protein phosphatase responsible for dephosphorylation of the Akt (Ser473) site. Akt (Ser473) is the TORC2 (mTOR) phosphorylation activation site. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1,000 , Optimal...

The amyloid beta-peptide (Ab) of 39-43aa (Ab40, Ab42, Ab43) is constitutively produced in brain upon proteolysis of the b-amyloid precursor protein (APP). In the young and healthy humans, Ab is rapidly catabolized before it can be deposited in the brain. However, upon aging or the onset of familial Alzheimer's...

Control Peptide for P4070-68A (affinity purified antibody) and P4070-68B (antiserum). The amyloid beta-peptide (Ab) of 39-43aa (Ab40, Ab42, Ab43) is constitutively produced in brain upon proteolysis of the b-amyloid precursor protein (APP). In the young and healthy humans, Ab is rapidly catabolized before it can be...

The amyloid beta-peptide (Ab) of 39-43aa (Ab40, Ab42, Ab43) is constitutively produced in brain upon proteolysis of the b-amyloid precursor protein (APP). In the young and healthy humans, Ab is rapidly catabolized before it can be deposited in the brain. However, upon aging or the onset of familial Alzheimer's...

Phosphacan is a soluble nervous tissue-specific proteoglycan that is thought to regulate axonal outgrowth. It is synthesized by glia. It inds to neurons and to the neural cell adhesion molecules tenascin, N-CAM or NG-CAM. It does not bind to laminin and fibronectin. Phosphacan acts as a potent inhibitor of cell...

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53...

PHLPP2, a protein phosphatase and negative regulator, which mediates the inactivation of Akt and protein kinase C (PKC) activity, through the direct dephosphorylation of key regulatory sites: AKT1 (Ser473), PRKCA (Ser657) and PRKCB isoform beta-II (Ser660). PHLPP2, and its alternative isoform PHLPP1, have been...