Bemerkungen: OspB, is one of the major Outer Surface Proteins of the outer membrane of Borrelia burgdorferi, which is composed of various unique outer surface proteins (Osp) that have been characterized (OspA through OspF). The Osp proteins are lipoproteins anchored by N-terminally attached fatty acid molecules to the membrane. They are presumed to play a role in virulence, transmission, or survival in the tick. Two of the major surface Ag of Borrelia burgdorferi, the 31-kDa OspA and 34-kDa OspB proteins, show a high degree of sequence similarity, are encoded by a 49-kb plasmid and share a common promoter, and are coordinately transcribed. OspA, OspB, and OspD are expressed by B. burgdorferi residing in the gut of unfed ticks, suggesting that they promote the persistence of the spirochete in ticks between blood meals. OspB has a contributing role in the adherence of B. burgdorferi to the tick gut. The C terminus of OspB is important for eliciting a protective immune response to OspB. B. burgdorferi has the ability to vary its surface proteins in response to immune attack.
ART NR.: 200-401-C15S (25 µl)
200-401-C15 (100 µg)
Anwendungen: ELISA, WB
Reaktivität: Borrelia burgdorferi
Immunogen: MBP-fusion protein corresponding to Borrelia burgdorferi OspB protein.
UniProt ID: P17739 | Suche mit UniProt ID
Gene ID: Gene ID 1194340 | Suche mit Gene ID
Schlagworte: Anti-ospB, Anti-BB_A16, Anti-Outer surface protein B
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