Anti-Myeloperoxidase (Clone 5F6)

Anti-Myeloperoxidase (Clone 5F6)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15640-1 1 each -

6 - 10 business days*

422.00€
 
Myeloperoxidase (MPO) is a heme-containing enzyme and the most abundant protein in... more
Product information "Anti-Myeloperoxidase (Clone 5F6)"
Myeloperoxidase (MPO) is a heme-containing enzyme and the most abundant protein in polymorphonuclear leukocytes (PMNs). It is comprised of two subunits linked by a disulfide bridge with each subunit containing a light and a heavy polypeptide chain. It can oxidize a variety of substrates and catalyzes the formation of highly reactive (pseudo)hypohalous acids and radicals, including hypochlorous acid. MPO is stored in azurophilic granules of PMNs and is released from activated or necrotic PMNs, after which it can bind to and modify acidic serum proteins, as well as recruit additional PMNs. MPO also has roles in PMN apoptosis and antimicrobial defense systems, including neutrophil extracellular traps (NETs). MPO-deficient mice exhibit reduced survival in a polymicrobial sepsis model, increased susceptibility to experimental autoimmune encephalomyelitis (EAE), and increased atherosclerosis in mice also deficient in the LDL receptor and fed an atherogenic diet. Cayman's Myeloperoxidase Monoclonal Antibody (Clone 5F6) was developed by fusing the spleen of a non-immunized NZBWF1 mouse with a mouse myeloma cell line and can be used for immunofluorescence (IF) applications.Synonyms: MPO. Clone Designation: 5F6. Formulation: (Request formulation change), 200 µg of affinity-purified monoclonal antibody. Storage Buffer: 200 µl PBS, pH 7.2, with 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide. Host: Mouse. Isotype: IgG2b. Applications: IF.
Keywords: MPO
Supplier: Cayman Chemical
Supplier-Nr: 15640

Properties

Application: IF
Antibody Type: Monoclonal
Clone: 5F6
Conjugate: No
Host: Mouse
Species reactivity: human
Format: Solid

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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