Anti-Melanocortin-4 Receptor

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10006355-1 1 each -

6 - 10 business days*

422.00€
 
Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis,... more
Product information "Anti-Melanocortin-4 Receptor"
Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'. These actions are mediated (differentially or concurrently) in part by a family of G protein-coupled receptors, the melanocortin receptors 1-5 (MC1R-MC5R). Melanocortin-4 receptor (MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain. Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation. Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity. All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE. Cayman's MC4R Polyclonal Antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.Synonyms: MC4R. Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: IHC (formalin-fixed paraffin-embedded sections) and WB. UniProt Accession #: P56450. Origin: Animal/Rabbit.
Keywords: Anti-Mc4r, Anti-MC4-R, Anti-MC4-R, Anti-Melanocortin receptor 4, Anti-Melanocortin receptor 4
Supplier: Cayman Chemical
Supplier-Nr: 10006355

Properties

Application: IHC (paraffin), WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: mouse
Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R
Format: Solid

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Melanocortin-4 Receptor"
Write a review
or to review a product.
Viewed