Anti-MSH2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-451A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A300-451A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms two... more
Product information "Anti-MSH2"
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. [The UniProt Consortium]
Keywords: Anti-MSH2, Anti-hMSH2, Anti-MutS protein homolog 2, Anti-DNA mismatch repair protein Msh2
Supplier: Bethyl Laboratories
Supplier-Nr: A300-451A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: dog, pig, panda, orangutan, rhesus monkey, gorilla, primates, green monkey, red guenon, crab-eating macaque, bornean orangutan, naked mole rat, black-pencilled marmoset, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by A300-451A maps to a region between residues 1 and 50 of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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