19 products were found matching "Cay13715-100"!

15(R)-PGE1 is the "unnatural" C-15 stereoisomer of PGE1. It is essentially inactive biologically when compared to PGE1. It is a non-competitive inhibitor of 15-hydroxy PGDH with an IC50 of 189 µM.Formal Name: 9-oxo-11alpha,15R-dihydroxy-prost-13E-en-1-oic acid. CAS Number: 20897-91-0. Synonyms: 15(R)-PGE1, 15-epi...

The CYP1A is a petroleum/PAH/PCB/dioxin-inducible protein (Mr = 55,000-59,000) in liver samples from a wide variety of fish species.Synonyms: C02406101, Cytochrome P450 1A (Cod). Immunogen: Atlantic cod (Gadus morhua L.) CYP1A, purified from liver microsomes of beta-naphthoflavone-treated cod. Formulation: (Request...

DUN41875 is an inhibitor of stearyol-CoA desaturase 1 (SCD1, IC50 = 11.8 nM for the rat enzyme). It increases tetramerization of soluble alpha-synuclein and reduces mutant alpha-synuclein incorporation into tetramers in BE(2)-M17 neuroblastoma cells expressing a mutant alpha-synuclein containing three...

UR-144 N-(2-chloropentyl) analog is a synthetic cannabinoid which differs from the parent compound, UR-144 (Cay-11502), by the addition of chloride to the 2 position of the pentyl chain. The physiological and toxicological properties of this compound have not been studied. This product is intended for forensic and...

Synonyms: Cytochrome P450 1A (fish). Immunogen: rainbow trout CYP1A amino acid sequence 190-204 and 282-296. Formulation: (Request formulation change), Purified IgG in 0.1 M sodium phosphate, pH 7.4, containing 0.15 M sodium chloride, 12.3 mM sodium azide, and 1% BSA. Host: Rabbit. Applications: ELISA and WB....

JWH 018 7-hydroxyindole metabolite-d9 contains nine deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5, and 5 positions. It is intended for use as an internal standard for the quantification of JWH 018 7-hydroxyindole metabolite by GC- or LC-mass spectrometry (MS). JWH 018 7-hydroxyindole metabolite is a minor...

Didanosine is an antiviral nucleoside analog and an inhibitor of reverse transcriptase. It undergoes cellular amination and phosphorylation to its active triphosphate form, 2',3'-dideoxyadenosine 5'-triphosphate (ddATP, Cay-17460). Didanosine inhibits human T cell leukemia virus type 1 (HTLV-1) reverse transcriptase...

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) amide is an FTS derivative with an amide added to the carboxyl group. FTS amide inhibits the growth of PANC-1 and U87 tumor cells with IC50 values of 20 and 10 µM,...

SLF1081851 is an inhibitor of sphingosine-1-phosphate (S1P) transporter (SPNS2). It inhibits mouse Spns2 by 67% when used at a concentration of 2 µM. SLF1081851 inhibits S1P export from HeLa cells expressing mouse Spns2 (IC50 = 1.93 µM). In vivo, SLF1081851 (20 mg/kg) decreases blood lymphocyte numbers and plasma...

Tivantinib is an inhibitor of c-Met (Ki = 0.355 µM). It is selective for c-Met over a panel of 229 additional kinases at 10 µM. Tivantinib also inhibits tubulin polymerization in a cell-free assay in a concentration-dependent manner. It is cytotoxic to c-Met-dependent and -independent cancer cell lines when used at...

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to...

A common metabolic pathway for several prostaglandins (PGs), including prostaglandin D2 (PGD2), involves the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the alpha-terminus and oxidation of the...