- Search results for Cay13787
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9 products were found matching "Cay13787"!
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Item number: Cay13877-10
Bleomycin is a glycopeptide antitumor antibiotic produced by the bacterium S. verticillus. Its mechanism of action causes single- and double-strand DNA breaks in tumor cells, which interrupts the cell cycle. Bleomycin is thought to achieve this by chelating metal ions, producing a pseudoenzyme that reacts with...
Keywords: | Blenoxane, bleomycin sulfate (salt) |
Application: | Apoptosis inducer |
CAS | 9041-93-4 |
MW: | 1415.6 D |
From 40.00€
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Item number: Cay17387-5
GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms alpha, delta, and gamma (IC50s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kbeta. It is over 1,000-fold selective for p100alpha over other PI3K-like kinases, including DNA-dependent protein kinase...
Keywords: | Taselisib,... |
Application: | PI3K alpha, delta, gamma inhibitor |
CAS | 1282512-48-4 |
MW: | 460.5 D |
From 50.00€
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Item number: Cay18377-5
Dihydroorotate dehydrogenase (DHODH) is involved in pyrimidine nucleoside biosynthesis. DHODH inhibitors have value in autoimmune diseases as well as cancer and certain infections. Vidofludimus is an immunosuppressive drug that inhibits DHODH (IC50s = 0.134, 1.29, and 10.6 µM for human, rat, and mouse isoforms,...
Keywords: | 4SC-101, 2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid |
Application: | Dihydroorotate dehydrogenase (DHODH) inhibitor |
CAS | 717824-30-1 |
MW: | 355.4 D |
From 50.00€
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Item number: Cay17378-5
AZD 2014 is a potent, selective, ATP-competitive mTORC1/2 dual inhibitor that inhibits phosphorylation of both mTORC1 and 2 substrate proteins in whole cells. It exhibits an IC50 value of 2.81 nM against the isolated recombinant enzyme and >1,000-fold selectivity against all PI3K isoforms. AZD 2014 has broad...
Keywords: | Vistusertib, 3-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-N-methyl-benzamide |
Application: | mTORC1/2 dual inhibitor |
CAS | 1009298-59-2 |
MW: | 462.5 D |
From 43.00€
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Item number: Cay37187-10
Dihydrothymine is a metabolite of the pyrimidine nucleobase thymine. It is formed from thymine by dihydropyrimidine dehydrogenase (DPD). Dihydrothymine can also be produced from thymine by UV radiation. Levels of dihydrothymine are elevated during the epithelial-to-mesenchymal transition (EMT) in human mammary...
Keywords: | 5,6-Dihydro-5-methyluracil, 5,6-Dihydrothymine, 5-Methyl-5,6-dihydrouracil, NSC 44131,... |
Application: | Thymine metabolite |
CAS | 696-04-8 |
MW: | 128.1 D |
From 35.00€
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Item number: Cay13781-1
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various...
Keywords: | Anti-H3FA, Anti-H3FL, Anti-H3FB, Anti-H3FD, Anti-H3FI, Anti-H3FH, Anti-H3FK, Anti-H3FF, Anti-H3FJ, Anti-Histone H3.1,... |
Application: | ELISA, FC, IP, WB |
Host: | Rabbit |
Species reactivity: | human |
422.00€
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Item number: Cay13784-1
Histone H3.3 is a nuclear protein and a replication-independent member of the histone H3 family that has a role in nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped...
Keywords: | H3.3A, H3.3B, H3F3A, H3F3B |
Application: | IHC, WB |
Host: | Rabbit |
Species reactivity: | chicken, ovine, Drosophila, equine, human, murine, opossum |
442.00€
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Item number: Cay33787-1
PRN-1371 is an irreversible covalent pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively). It is selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 µM for all) but does inhibit colony stimulating factor 1 receptor (CSF1R) activity by...
Keywords: | 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]propyl]-pyrido[2,3-d]pyri... |
Application: | Irreversible pan-FGFR inhibitor |
CAS | 1802929-43-6 |
MW: | 561.5 D |
From 94.00€
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Item number: Cay31787-1
Dronedarone-d6 is intended for use as an internal standard for the quantification of dronedarone (Cay-9000543) by GC- or LC-MS. Dronedarone is an antiarrhythmic agent and a derivative of amiodarone (Cay-15213). It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol...
Keywords: | N-[2-butyl-3-[4-[3-(dibutylamino)propoxy-1,1,2,2,3,3-d6]benzoyl]-5-benzofuranyl]-methanesulfonamide, monohydrochloride |
Application: | GC-MS, LC-MS, Quantification, Internal standard, Antiarrhythmic agent |
CAS | 1329809-23-5 |
MW: | 599.3 D |
564.00€
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