18 products were found matching "BPS-25298"!

HMG2L1 (UniProtKB/Swiss Prot entry Q9UGU5) is a negative regulator of Wnt/beta catenin signaling during development

HP1 alpha (UniProt/Swiss Prot entry P45973) is a component of heterochromatin. It recognizes and binds to histone H3 tails methylated at Lys 9, leading to epigenetic repression of transcription. HP1 alpha may also interact with lamin B receptor (LBR), thereby contributing to the association of the heterochromatin...

HP1 alpha, beta and gamma (UniProt/Swiss Prot entry P45973, P83916 and Q13185) are components of heterochromatin. They recognize and bind histone H3 tails methylated at Lys 9, leading to epigenetic repression of transcription. HP1 alpha, beta and gamma also interact with lamin B receptor (LBR), thereby contributing...

JARID1B (UniProt/Swiss Prot entry Q9UGL1) is a histone demethylase which specifically demethylates mono , di, and trimethylated lysine 4 of histone H3. It acts as a transcriptional repressor for the tumor suppressor genes BRCA1 and HOXA5 and has been associated with breast cancer development. In contrast, in...

Jarid1c (UniProtKB/Swiss Prot entry P41229) is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a central role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form....

JARID2 (UniProtKB/Swiss Prot entry Q92833) is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. JARID2 acts by recruiting histone methyltransferase complexes (PRC2) to their...

JMJD2a (UniProtKB/Swiss Prot entry O75164), belongs to the JMJD2 family of histone demethylases which play an important role in the establishment of the histone code. JMJD2a specifically demethylates the trimethylated K9 and K36 of histone H3, thereby converting these lysines to the dimethylated form. It has no...

JMJD2b (UniProtKB/Swiss Prot entry O94953), belongs to the JMJD2 family of histone demethylases which play an important role in the establishment of the histone code. JMJD2b specifically demethylates the trimethylated K9 of histone H3. It is not able to demethylate K4, K27 and K36 of histone H3, nor K20 of histone H4.

KDM1B (UniProtKB/Swiss Prot entry Q8NB78), also known as LSD2, is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono and di methylated lysine 4 of histone H3, but has no...

HDAC3 (UniProt/Swiss Prot entry O15379) catalyses the deacetylation of lysine residues in the N terminal part of the core histones (H2A, H2B, H3 and H4). Acetylation and deacetylation of these highly conserved lysine residues is important for the control of gene expression and HDAC activity is associated with gene...

The AML1 (RUNX1) (UniProtKB/Swiss-Prot entry Q01196) - ETO (RUNX1T1) (UniProtKB/Swiss-Prot entry Q06455) fusion protein arises due to a translocation between chromosome 8 and 22 (t(8,21)(q22,q22)). This translocation is one of the most frequent karyotypic abnormalities observed in acute myeloid leukaemia. It...

DNMT3A (UniProtKB/Swiss Prot entry Q9Y6K1) catalyses the genome wide de novo methylation of CpG residues. DNA methylation on CpG residues by DNMT3A regulates gene expression and is essential for development. DNMT3A is strongly expressed in embryonic stem cells, but low in adult somatic cells. DNA methylation is...