- Search results for Cay14701
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10 products were found matching "Cay14701"!
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Item number: Cay14701-1
Jumonji AT rich interactive domain 1B (JARID1B) nuclear proteins are potential histone demethylases. JARID1B demethylation of Lys-4 of histone H3 plays an important role in breast cancer cell proliferation through BRCA1 repression. JARID1B acts as a transcriptional co-repressor of two developmental transcription...
Keywords: | Anti-CT31, Anti-CT31, Anti-KDM5B, Anti-PLU-1, Anti-PLU-1, Anti-JARID1B, Anti-RBP2-H1, Anti-RBP2-H1, Anti-Cancer/testis... |
Application: | FC, ICC |
Host: | Rabbit |
Species reactivity: | human |
422.00€
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Item number: Cay14470-1
UR-144 N-(2-hydroxypentyl) isomer is a synthetic cannabinoid that differs from the parent compound, UR-144 (Cay-11502), by the addition of a hydroxyl group to the alkyl chain. It is a potential metabolite of UR-144, based on the first pass metabolism of similar compounds by cytochrome P450 in the liver. The...
Keywords: | (1-(2-hydroxypentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone |
Application: | Analytical reference standard, Synthetic cannabinoid analog, Potential UR-144 metabolite |
CAS | 2748288-94-8 |
MW: | 327.5 D |
From 339.00€
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Item number: Cay14703-1
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor, have been implicated in the development and progression of several human cancers. PHA-665752 is an ATP-competitive, active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM, IC50 = 9 nM). It exhibits >50-fold selectivity...
Keywords: | (3Z)-5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-... |
Application: | ATP-competitive, active-site c-Met kinase inhibitor |
CAS | 477575-56-7 |
MW: | 641.6 D |
From 66.00€
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Item number: Cay14705-1
Vildagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4, Ki = 0.003 µM). It is selective for DPP-4 over DPP-2, DPP-8, and DPP-9 (Kis = >500, 0.81, and 0.095 µM, respectively). Vildagliptin (3 mg/kg) decreases plasma glucose levels and increases plasma insulin levels during an oral glucose challenge in Zucker...
Keywords: | 1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2S-pyrrolidinecarbonitrile |
Application: | DPP4 / DPP8 / DPP9 inhibitor |
CAS | 274901-16-5 |
MW: | 303.4 D |
From 39.00€
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Item number: Cay14709-1
FSLLRY-amide is a peptide antagonist of protease-activated receptor (PAR) 2 which blocks activation by trypsin (IC50 = ~50 µM) but not by the synthetic agonist SLIGRL-NH2 (Cay-16723). It does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein. It can be used to study PAR2 action...
Keywords: | L-phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide |
Application: | PAR2 antagonist |
CAS | 245329-02-6 |
MW: | 797 D |
From 119.00€
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Item number: Cay14708-1
3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC50 = 26 nM). It less effectively inhibits a panel of...
Keywords: | N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide |
Application: | PDK1 inhibitor |
CAS | 702674-56-4 |
MW: | 471.4 D |
From 61.00€
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Item number: Cay14702-1
PORCN is a porcupine homolog protein that belongs to the evolutionary conserved porcupine gene family. Genes of this family encode multi-pass endoplasmic reticulum proteins. Porcupine proteins play an important role in regulating Wnt signaling. Deficiency or mutation in X-linked PORCN causes focal dermal...
Keywords: | Anti-Protein MG61, Anti-Protein MG61, Anti-Protein-serine O-palmitoleoyltransferase porcupine, Anti-Protein-serine... |
Application: | FC, IF, WB |
Host: | Rabbit |
488.00€
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Item number: Cay14750-1
16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme. Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist on most EP receptor subtypes, and has been used experimentally to...
Keywords: | 16,16-dimethyl PGE2, 9-oxo-11alpha,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid |
Application: | PGDH inhibitor |
CAS | 39746-25-3 |
MW: | 380.5 D |
From 115.00€
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Item number: Cay14790-1
The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
Keywords: | (25R)-26-hydroxy Cholesterol, (25R)-cholest-5-ene-3beta,26-diol |
Application: | LXR alpha / beta activator |
CAS | 20380-11-4 |
MW: | 402.7 D |
From 77.00€
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Item number: Cay14720-1
15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Cay-14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH). Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 µM, respectively) or induce adenylate cyclase activity...
Keywords: | 15-keto PGE2, 9,15-dioxo-11alpha-hydroxy-prosta-5Z,13E-dien-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 26441-05-4 |
MW: | 350.5 D |
From 88.00€
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