10 products were found matching "Cay14701"!

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Anti-JARID1B/PLU1 (C-Term)
Anti-JARID1B/PLU1 (C-Term)

Item number: Cay14701-1

Jumonji AT rich interactive domain 1B (JARID1B) nuclear proteins are potential histone demethylases. JARID1B demethylation of Lys-4 of histone H3 plays an important role in breast cancer cell proliferation through BRCA1 repression. JARID1B acts as a transcriptional co-repressor of two developmental transcription...
Keywords: Anti-CT31, Anti-CT31, Anti-KDM5B, Anti-PLU-1, Anti-PLU-1, Anti-JARID1B, Anti-RBP2-H1, Anti-RBP2-H1, Anti-Cancer/testis...
Application: FC, ICC
Host: Rabbit
Species reactivity: human
422.00€ *
Review
UR-144 N-(2-hydroxypentyl) metabolite
UR-144 N-(2-hydroxypentyl) metabolite

Item number: Cay14470-1

UR-144 N-(2-hydroxypentyl) isomer is a synthetic cannabinoid that differs from the parent compound, UR-144 (Cay-11502), by the addition of a hydroxyl group to the alkyl chain. It is a potential metabolite of UR-144, based on the first pass metabolism of similar compounds by cytochrome P450 in the liver. The...
Keywords: (1-(2-hydroxypentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
Application: Analytical reference standard, Synthetic cannabinoid analog, Potential UR-144 metabolite
CAS 2748288-94-8
MW: 327.5 D
From 339.00€ *
Review
PHA-665752
PHA-665752

Item number: Cay14703-1

The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor, have been implicated in the development and progression of several human cancers. PHA-665752 is an ATP-competitive, active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM, IC50 = 9 nM). It exhibits >50-fold selectivity...
Keywords: (3Z)-5-[[(2,6-dichlorophenyl)methyl]sulfonyl]-3-[[3,5-dimethyl-4-[[(2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl]carbonyl]-...
Application: ATP-competitive, active-site c-Met kinase inhibitor
CAS 477575-56-7
MW: 641.6 D
From 66.00€ *
Review
Vildagliptin
Vildagliptin

Item number: Cay14705-1

Vildagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4, Ki = 0.003 µM). It is selective for DPP-4 over DPP-2, DPP-8, and DPP-9 (Kis = >500, 0.81, and 0.095 µM, respectively). Vildagliptin (3 mg/kg) decreases plasma glucose levels and increases plasma insulin levels during an oral glucose challenge in Zucker...
Keywords: 1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2S-pyrrolidinecarbonitrile
Application: DPP4 / DPP8 / DPP9 inhibitor
CAS 274901-16-5
MW: 303.4 D
From 39.00€ *
Review
FSLLRY-amide
FSLLRY-amide

Item number: Cay14709-1

FSLLRY-amide is a peptide antagonist of protease-activated receptor (PAR) 2 which blocks activation by trypsin (IC50 = ~50 µM) but not by the synthetic agonist SLIGRL-NH2 (Cay-16723). It does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein. It can be used to study PAR2 action...
Keywords: L-phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide
Application: PAR2 antagonist
CAS 245329-02-6
MW: 797 D
From 119.00€ *
Review
BX-912
BX-912

Item number: Cay14708-1

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC50 = 26 nM). It less effectively inhibits a panel of...
Keywords: N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Application: PDK1 inhibitor
CAS 702674-56-4
MW: 471.4 D
From 61.00€ *
Review
Anti-PORCN
Anti-PORCN

Item number: Cay14702-1

PORCN is a porcupine homolog protein that belongs to the evolutionary conserved porcupine gene family. Genes of this family encode multi-pass endoplasmic reticulum proteins. Porcupine proteins play an important role in regulating Wnt signaling. Deficiency or mutation in X-linked PORCN causes focal dermal...
Keywords: Anti-Protein MG61, Anti-Protein MG61, Anti-Protein-serine O-palmitoleoyltransferase porcupine, Anti-Protein-serine...
Application: FC, IF, WB
Host: Rabbit
488.00€ *
Review
16,16-dimethyl Prostaglandin E2
16,16-dimethyl Prostaglandin E2

Item number: Cay14750-1

16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme. Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist on most EP receptor subtypes, and has been used experimentally to...
Keywords: 16,16-dimethyl PGE2, 9-oxo-11alpha,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid
Application: PGDH inhibitor
CAS 39746-25-3
MW: 380.5 D
From 115.00€ *
Review
25(R)-27-hydroxy Cholesterol
25(R)-27-hydroxy Cholesterol

Item number: Cay14790-1

The liver X receptors (LXRalpha and LXRbeta) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism. 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRalpha and LXRbeta in...
Keywords: (25R)-26-hydroxy Cholesterol, (25R)-cholest-5-ene-3beta,26-diol
Application: LXR alpha / beta activator
CAS 20380-11-4
MW: 402.7 D
From 77.00€ *
Review
15-keto Prostaglandin E2
15-keto Prostaglandin E2

Item number: Cay14720-1

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Cay-14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH). Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 µM, respectively) or induce adenylate cyclase activity...
Keywords: 15-keto PGE2, 9,15-dioxo-11alpha-hydroxy-prosta-5Z,13E-dien-1-oic acid
Application: Bioactive lipid assays
CAS 26441-05-4
MW: 350.5 D
From 88.00€ *
Review