Anti-Interleukin-33 (Clone IL333068A)

Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL-33 is converted by CASP1 to a 18 kDa protein. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy and anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.Synonyms: IL-1F11, IL-33, NF-HEV. Immunogen: Recombinant human IL-33. Clone Designation: IL333068A. Formulation: (Request formulation change), 50 or 100 µg of protein G-purified antibody. Storage Buffer: PBS, pH 7.4. Host: Mouse. Isotype: IgG2bkappa. Applications: ELISA, WB. Cross Reactivity: (+) Human IL-33, (+) Murine IL-33 (weakly). Origin: Animal/Mouse.