12 products were found matching "Cay10810"!

Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL-33 is converted by CASP1 to a 18 kDa protein. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation...

HZ-52 is a potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 µM in intact human polymorphonuclear leukocytes. HZ-52 also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in...

Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC) is an inhibitor of 5-lipoxygenase (5-LO, IC50 = 15 nM). It is selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively). CDC inhibits 5-LO product formation induced by the calcium ionophore A23187 (Cay-11016) in isolated human polymorphonuclear...

(±)-Norepinephrine-d6 is intended for use as an internal standard for the quantification of norepinephrine (Cay-35580) by GC- or LC-MS. (±)-Norepinephrine is a racemic mixture of the endogenous neurotransmitter (-)-norepinephrine (Cay-16673) and (+)-norepinephrine. It induces cAMP accumulation in rat cerebral...

JWH 309 is a synthetic cannabinoid (CB) that displays high affinities for both the central CB1 receptor (Ki = 41 nM) and the peripheral CB2 receptor (Ki = 49 nM). The physiological and toxicological properties of this compound have not been examined. This product is intended for forensic and research...

JWH 073 is a synthetic cannabinoid (CB) that activates both the CB1 and the CB2 receptor (Ki = 8.9 and 38 nM, respectively). This cannabimimetic compound has been identified in herbal blends. JWH 073 2-methylnaphthyl analog (Cay-10848) differs structurally from JWH 073 by having a methyl group added at the 2...

JWH 016 (Cay-10849) is an analytical reference standard categorized as a synthetic cannabinoid. JWH 016 induces discriminative stimulus effects in rhesus monkeys comparable to those induced by Delta9-THC (Cay-ISO60157, Cay-12068). This product is intended for research and forensic applications.Formal Name:...

AM2201 is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the CB1 and CB2 receptors, respectively.Formal Name: (1-(5-fluoropentyl)-1H-indol-3-yl)(naphthalen-2-yl)methanone. CAS Number: 2365471-27-6. Molecular Formula: C24H22FNO. Formula Weight: 359.4. Purity: >98%. Formulation: (Request...

JWH 073 is a potent cannabimimetic that has been identified as an adulterant in smoking mixtures. (S)-(+)-JWH 073 N-(3-hydroxybutyl) metabolite (Cay-10898) is an analytical reference standard categorized as a synthetic cannabinoid metabolite. It is a metabolite of JWH 073 (Cay-10904). This product is intended for...

Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL-33 is converted by CASP1 to a 18 kDa protein. IL-33 binds to and signals through ST2 (IL1R1) and its stimulation...

Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid (CBA, item no. 14051) that can be used to detect peroxynitrite (Cay-81565), hypochlorous acid, and hydrogen peroxide. Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays...

ABL 127 is a covalent aza-beta-lactam inhibitor of protein phosphatase methylesterase-1 (PME-1, IC50 = 4.2 nM). It selectively inhibits PME-1 over 50 other serine hydrolases in MDA-MB-231 and HEK293T cell lysates at 10 µM. ABL 127 decreases proliferation of Ishikawa cells and migration of ECC-1 endometrial carcinoma...