Anti-Interleukin 12 receptor, Beta 2 (IL-12-Rb2 , beta 2 IL-12R-beta-2, IL-12 receptor beta-2, Int

IL­12 Rb2 is a type I cytokine receptor family protein that associates with IL 12 Rb1 to form a functional high affinity receptor complex for IL­12. The extracellular region of IL 12 Rb2 contains five fibronectin type 3 domains. The cytoplasmic region is alternatively spliced, giving rise to two isoforms. IL­12 Rb2 is upregulated in TH1 cells during inflammatory responses. The extracellular regions of human and mouse IL 12 Rb2 share 69% aa sequence identity. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml using Human Th1 cells, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.