Anti-Interferon-alpha/beta Receptor alpha chain (Ab-466)

Anti-Interferon-alpha/beta Receptor alpha chain (Ab-466)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABD-8B0952.50 50 µg -

3 - 8 business days*

601.00€
 
Custom conjugation services for this antibody as available (eg. labeling of... more
Product information "Anti-Interferon-alpha/beta Receptor alpha chain (Ab-466)"
Custom conjugation services for this antibody as available (eg. labeling of Anti-Interferon-alpha/beta Receptor alpha chain (Ab-466) with HRP. Available labels are AF: AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750. Proteins: HRP, Alkaline Phosphatase, Streptavidin. Tandems: APC, APC/Cy7, APC/AF750, APC/iFluor(TM) 700, APC/iFluor(TM) 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor(TM) 594, PE/iFluor(TM) 647, PE/iFluor(TM) 700, PE/iFluor(TM) 750, PE/Texas Red(R), PerCP, PerCP/Cy5.5. Small Molecules: Biotin. Traditional Dyes: FITC (Fluorescein), TRITC (Rhodamine), PacBlue, PacOrange, Cy3, Cy5. iFluor: 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7. mFluor: UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780. Protein function: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986, PubMed:32972995). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. [The UniProt Consortium]
Keywords: Anti-IFNAR, Anti-CRF2-1, Anti-IFNAR1, Anti-IFN-R-1, Anti-IFN-alpha/beta receptor 1, Anti-Type I interferon receptor 1, Anti-Interferon alpha/beta receptor 1, Anti-Cytokine receptor family 2 member 1, Anti-Cytokine receptor class-II member 1, Interferon-al
Supplier: AAT Bioquest
Supplier-Nr: 8B0952

Properties

Application: IHC, IF, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: synthetic peptide
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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